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The activation of mast cells caused the destruction of neighboring chondrocytes and the breakdown of cartilage.[ref] Related article: Osteoarthritis genes The figure below is from a study on mast cells in osteoarthritis (OA), showing both increased numbers of mast cells and an increase in tryptase

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Who Should Be Cautious or Talk to a Clinician First While B12 supplementation at standard doses is safe for most people, certain situations call for extra care and professional guidance